With Allegheny entering their playoffs and with the Great Midwest figuring out who will be in their playoffs, this is an important weekend.
Friday's Illinois State vs Northwestern game followed by Sunday's Loyola vs Northwestern makes it a massive weekend for the Wildcats.
Scranton plays Villanova in a key game in the MARC. Maine plays Vermont in a huge faceoff in the NEWCRC.
Check back for scores:
| 10/20 | Illinois State | 17-44 | Northwestern | Great Midwest |
| 10/20 | Chicago | 43-10 | UIC | Great Midwest |
| 10/21 | Western Kentucky | 12-49 | MTSU | Allegheny QFs |
| 10/21 | Eastern Kentucky | 0-28 | Miami | Allegheny QFs |
| 10/21 | West Virginia | 3-55 | Kent State | Allegheny QFs |
| 10/21 | Richmond | at | Old Dominion | Cardinals |
| 10/21 | George Mason | 0-28 | Hampden Sydney | Cardinals |
| 10/21 | Virginia | 55-5 | Emory and Henry | Cardinals |
| 10/21 | Washington and Lee | 14-29 | Radford | Cardinals |
| 10/21 | UMS&T | 0-62 | James Brown | Gateway |
| 10/21 | Calvin | 0-67 | CMU | Great Lakes |
| 10/21 | GVSU | 54-12 | Ferris | Great Lakes |
| 10/21 | UW-Platteville | 7-103 | Northern Iowa | Great Midwest |
| 10/21 | UW-Whitewater | 41-12 | UW-Milwaukee | Great Midwest |
| 10/21 | Cornell | at | Albany | Liberty |
| 10/21 | RPI | 33-10 | SUNY Oswego | Liberty |
| 10/21 | Bloomsburg | 21-36 | Lehigh | MARC North |
| 10/21 | Bucknell | 41-26 | East Stroudsburg | MARC North |
| 10/21 | Scranton | 12-29 | Villanova | MARC North |
| 10/21 | Georgetown | 70-12 | Mount St. Mary's Dev. | MARC South |
| 10/21 | Towson | Ppd | Drexel | MARC South |
| 10/21 | New Mexico State | at | Albuquerque RFC | NCR Ind. |
| 10/21 | Boston University | 13-12 | UMass Lowell | NEWCRC |
| 10/22 | Norwich | 85-7 | Bentley | NEWCRC |
| 10/21 | UNH | 5-43 | Coast Guard | NEWCRC |
| 10/21 | Maine | 27-20 | Vermont | NEWCRC |
| 10/21 | ND State | 12-55 | MSU Mankato | Northern Lights |
| 10/21 | St. Thomas | 27-21 | UM Duluth | Northern Lights |
| 10/21 | St. John's | 14-48 | UW Stout | Northern Lights |
| 10/21 | St. Scholastica | 0-28 | MSU Moorhead | Northern Lights |
| 10/21 | Memphis | 74-7 | Valdosta State | SCRC |
| 10/21 | Auburn | 61-5 | Ole Miss | SCRC |
| 10/21 | Tennessee Tech | 42-0 | Mississippi State | SCRC |
| 10/21 | Coastal Carolina | 56-19 | Appalachian St | SoCon D2 |
| 10/21 | Idaho State | L-W | Colorado Mesa | High Peaks |
| 10/21 | Western Colorado | W-L | UC - Colorado Springs | High Peaks |
| 10/22 | Loyola | 24-39 | Northwestern | Great Midwest |
| 10/22 | Northern Illinois | 14-37 | Chicago | Great Midwest |
| 10/22 | Hofstra | 12-36 | USMMA | Tri-State |
